However, after two brilliant goals from Mane and thumping Van Dijk header, the Reds had stunned the German champions away with a classic Liverpool performance in Europe, one which will be looked back in fondness for many years to come.
The result marked just the third defeat for the manager since taking over in December, and he will now have the worldwide break to regroup ahead of a final push for Champions League qualification.
With 36 goals to his name already this season, Messi will be confident of halting United's progress in this year's competition. Having already jettisoned two managers this season, the odds are heavily stacked against caretaker boss Scott Parker keeping them in the top flight and, with their next two matches against the teams now second and first in the league, the fixtures aren't falling kindly for them either. @ManUtd, " Pique wrote on Twitter.
The Champions League hasn't had a different victor since Barcelona claimed the title in 2015.
But despite winning three Bundesliga titles during his three years at Bayern Munich, Guardiola said his time in Germany is viewed as a failure and he believes it will be the same for his career at City, irrespective of domestic success.
Liverpool manager Jurgen Klopp said it is unlikely that the Reds will spend big on signings in the transfer market. United will be played on Wednesday April 10, with the second leg games on Tuesday April 16.
That pairing brought together the only two quarterfinalists who have never been European champion.
Liverpool have won 17, drawn four and lost six of their 27 Premier League meetings with the Cottagers.
Despite just a single point gap at the top of the standings, Manchester City remain -275 favorites to win the league while Liverpool are +225. "I could not be further away from thinking it's the best draw because it isn't".
The latter tie is a repeat of the 1996 final, which the Italian club won on penalties against an Ajax team who had won the trophy the previous year. But can they pull off another shock by eliminating Juventus, and Cristiano Ronaldo, from the competition?
The semi-final pairings were also made with Tottenham or City to face Ajax or Juventus and Manchester United or Barcelona to meet either Liverpool or Porto.
The final is scheduled for June 1 at the Metropolitano Stadium, the home of Atletico Madrid.