Chatting about everything from women's empowerment to Prince Harry and Meghan's future royal baby and the importance of education, the conversation highlighted how important it is to support women.
In recent months, the communications team at Kensington Palace has been increasingly deleting comments attacking Meghan, while also blocking abusive accounts on both Twitter and Instagram. The Duchess will be very sad to see her go, but is excited for her as Amy has exciting plans ahead including spending some time overseas.
Pregnant Meghan Markle has lost another staffer.
News of the resignation comes after Harry and Meghan lost three palace aides within six months of the royal wedding in May previous year.
Meghan, Duchess of Sussex.
Clean Bandit performing
"She has been with her since she moved from Canada and she will remain as a personal adviser to her in the long term".
A few months before the royal wedding in May of a year ago however, she was forced to close all of them. Meghan's personal assistant Melissa Touabti resigned just six months into the job.
Amy's departure will mean that all three of the main women working for Meghan will have left in a matter of months. Kensington Palace on Monday tweeted a statement of the list of guidelines as well as any consequences if they are not adhered to. She will be on hand to make sure any transition is seamless and her exit is said to be "amicable", ET's source adds.
Also, royal correspondent Richard Palmer has written, "It is clear that Meghan is regarded as hard and demanding by some in the family and on the staff".
Now the fact that the Duchess is losing Pickerill - who had previously been a senior communications officer for Prince William and Kate Middleton - is sure to cause more gossip about Harry's wife's alleged troublesome ways.