US First Lady Melania Trump holds a baby during a visit to a hospital after she began a week-long trip to Africa on Tuesday to promote her "Be Best" campaign.
While speaking about her experience on Wednesday, the first lady said she was "very emotional" during her visit to the historic site, and described it as something she would "never forget".
Mrs. Trump is visiting Africa on her first extended solo global tour as first lady.
Osabarima Kwesi Atta II also said the fishermen and elders have been asked to look out for people who continue to defecate along the coast.
The mood before the arrival of the First Lady and her entourage was euphoric, as the Apamkro Cultural Troupe from the University of Cape Coast Primary School waited patiently to welcome the First Lady with their mmensuon (flute) performance.
"When these visits happen, it makes you feel important and hence live up to that standard", and makes Cape Coast important to the rest of the world.
The Emintsimadze Palace was decked in Ghana and U.S. flags, with a banner carrying a picture of American First Lady and the inscription, "Akwaaba to Cape Coast H.E. Melania Trump".
Former President Barack Obama and his family toured the castle in 2009.
President Trump denied sleeping with Daniels, real name Stephanie Clifford, in 2006, a year after getting married to Melania, and shortly after she gave birth to their son Barron.
She arrived in the West African nation of Ghana after an overnight flight from Washington and quickly made her way to the Greater Accra Regional Hospital.
The contrast with last week's high drama over Donald Trump's nomination to the Supreme Court was telling, as a relaxed-looking first lady visited a hospital in Ghana's capital, Accra, to meet mothers and their newborns.
Much like she did in 2017, Melania wore the designer item with a pair of cropped khaki cigarette trousers, and snakeskin footwear - however she traded the pricey Manolo Blahnik heels she wore past year in favor of some budget-friendly $49.95 loafers from Zara. She also has stops planned this week in Malawi, Kenya and Egypt.
The most surprising fashion repeat however was in March 2017, when Melania wore the same $3,000 Valentino dress two days in a row - first modeling it in the Oval Office, while supporting her husband as he signed a new bill aimed at encouraging women to pursue careers in science, technology, engineering and mathematics (STEM).
"It's really, really touching", she said.