City suffered a shock 2-1 defeat at home to Lyon in their first Group F game while Hoffenheim drew 2-2 at Shakhtar Donetsk.
Sergio AGUERO scored goal number 8 of the season in Manchester City's 2-1 win against Hoffenheim in the Champions League.
This week they get a team that has failed to get off to a good start in the Bundesliga losing three of their first six matches. "A win in Germany is always so complicated and we will learn so it's a good three points because we fought against a lot of things", he said, before admitting City were tentative before the break.
This is Turkey's fourth defeat in the last five Euro bidding races and they had been hoping to mark the republic's 100th anniversary in 2024 by staging their first major global football tournament.
If the Manchester City manager wants to make changes he can look to his bench, where options available include Gabriel Jesus and Riyad Mahrez.
Raheem Sterling then had a glorious chance to put the Citizens ahead as a blistering counter-attack had the English winger with just Oliver Baumann to beat, but his shot found the heel of the goalkeeper before going wide.
City defender Kyle Walker was fortunate to escape with just a yellow card for a bad challenge on Pavel Kaderabek in the second half, while the visitors thought they should have had a penalty when Baumann appeared to bring down Sane after missing the ball.
The visitors pushed for a victor, with Aguero and Raheem Sterling both thwarted by Oliver Baumann in the Hoffenheim goal.
The second goal arrived midway through the first half, with Dybala firing home from close range after Blaise Matuidi's initial effort was saved.
"I've never seen so many Man Utd players, who I'd normally hang my hat on, give the ball away so much", he said.
Guardiola heaped praise on match-winner Silva, 32.