The pilot is being checked for injuries.
The service did not give a suspected cause for the crash, saying the incident remained under investigation.
A military pilot has ejected safely after a a plane crash in Beaufort County, South Carolina, according to authorities there.
The crash took place about 4 miles west of Marine Corps Air Station Beaufort.
No-one on the ground was hurt either in the crash.
Ultimately, the Air Force intends to purchase 1,763 F-35As, the Marine Corps intends to buy 353 F-35Bs and the Navy plans to buy 340 F-35Cs designed for deployment on aircraft carriers. Its announced price tag is $115.5 million, a figure that includes the airframe, engine and associated contractor costs. On Friday V Adm Mat Winter, head of the Pentagon's F-35 office, said: "Driving down cost is critical to the success of this programme".
It comes one day after a Marine Corps F-35B conducted its first-ever airstrike in Afghanistan. It is also home to five squadrons that fly various versions of F/A-18 Hornet fighter jets.
The F-35B is a variant of the F-35 and is the only one with the ability to land vertically similar to a helicopter.
The F-35B stealth fighter jet was used by the United States in combat this week for the first time, against the Taliban in Afghanistan, after taking off from an amphibious assault ship in the Arabian Sea.
US President Donald Trump has praised the F-35's "super stealth" technology.