Xherdan Shaqiri will start his first game in competitive action since signing for Liverpool in the summer and given his bright and energetic cameos so far this season, the Switzerland global should help his team to a seventh consecutive win.
Salah removed his undershirt as he prepared to take a corner in the first half and there was clearly some serious strapping on the shoulder he injured in a clash with Sergio Ramos during last year's Champions League final.
And just before half time, Mohamed Salah made it three with his third of the season.
"If we had been dominated in the game and poor for long periods, which was not the case, we would have been more concerned going up against an in-form Liverpool team". It is a completely normal situation for an offensive player that they have times when they don't score. But he is still a threat, had fantastic situations in both games and he is in good shape. "I would never do that, the players should never do that - only the supporters are allowed to do that".
Liverpool shelled out some £75million to sign Virgil van Dijk from Southampton in January, which was a world-record fee for a defender.
Liverpool have gone 750 minutes without conceding a Premier League goal at Anfield, keeping eight clean sheets in a row.
21' - GOAL! Liverpool 2-0 Southampton (Matip).
A rule enforced by the FA dictates that live football in the United Kingdom can not be broadcast between 2.45pm and 5.15pm on a Saturday.
"You've all seen the "no look" goals so I think he doesn't need his eye to play".
Fan will be able to see highlights of all the Premier League's action on BBC's Match of the Day every Saturday night.
Liverpool vs Southampton: Who will win?