Referee Felix Brych showed Ronaldo a straight red card after discussing with his assistant behind the goal.
But Juventus, who had totally dominated until Ronaldo's dismissal, were awarded two penalties within six minutes either side of half-time, and Miralem Pjanic confidently dispatched them both.
Ronaldo looked baffled and kept professing his innocence and was clearly distraught as he left the pitch in tears, still shaking his head.
There us still hope for Ronaldo and his Manchester United reunion at Old Trafford however as he may only be suspended for one game rather than three, depending on what the UEFA disciplinary panel decide.
Ronaldo's first send off in 154 Champions League appearances sparked reaction from across the world from pundits and fans alike, with most commentators miffed over the referee's ruling, failing to understand how the official thought the clash with Murillo was bad enough to warrant send off without giving Ronaldo a warning first.
Cristiano Ronaldo was sent off in the 29th minute of his first Champions League match with Juventus on an absurdly soft call. "It's disappointing because now we'll lose him for a few games and instead if there had been VAR it would have been seen that it wasn't a sending-off offence".
"You could say he's increased the players' desire to prove themselves", Allegri said. It has lost five finals since then and hoped that signing Ronaldo, who has won the competition five times, it could go one step further.
Luckily, Juventus was still able to pull out the win, quickly taking a 2-0 lead despite being down to ten men.
Valencia's defense immediately reacted, and Ronaldo was eventually given a red card for his infraction.
Ramos, 32, passes former Manchester United midfielder Paul Scholes as the most cautioned player in the competition and also holds the record for the most yellow cards in a single Champions League campaign, picking up five bookings in the 2010-11 and 2012-13 seasons. First, Parejo missed a high ball and kicked Joao Cancelo before Murillo took a risk by bundling down Leonardo Bonucci.
Parejo stepped up but Wojciech Szczesny saved his spot-kick to sum up the Spanish side's frustrating evening.