With no replay allowed for her iconic all-in-one outfit, Williams instead opted for a piece from the Nike, Serena Williams and Virgil Abloh collaboration.
'Speaking to Vogue a year ago, she had this to say: "Being a Jehovah's Witness is important to me, but I've never really practiced it and have been wanting to get into it. 'Alexis didn't grow up going to any church, but he's really receptive and even takes the lead".
Serena Williams can match Margaret Court's all-time record of 24 majors with another title at Flushing Meadows.
Williams' dress featured a one-shoulder silhouette, with a long left sleeve and a sheer sleeveless cut on the right, as well as the all-important, layered short tulle ballet skirt. Even Minaj, whose new album is titled Queen, took to Instagram to give all praise to Williams.
Another said: "They didn't let Serena Williams wear her catsuit".
And if you're wondering what was Serena Williams wearing for her big return that became a big sensation after she wore an eye-catching medical catsuit that ultimately made French Open officials ban it?
The world number one was scheduled first on the new Louis Armstrong Stadium against Kaia Kanepi and lasted just an hour and 15 minutes before succumbing to a 6-2 6-4 defeat.
"There's still several matches to play before you're there", Williams told reporters about a possible matchup with her sister.
"When I first tried on the dress, I felt very strong and feminine at the same time".
Two-time Australian Open champion Victoria Azarenka is back in NY for the first time in three years as a wild card after the birth of son Leo and then the custody battle that limited her travel, and she battled to a 6-3 7-5 victory over Viktoria Kuzmova. "No one's ideal, [they're] always talking about our bodies and what we can wear and what we can't wear and I don't hear too much about the guys, do you?" "I'm super excited to get the tournament going".
Stephens, seeded third behind Halep and Caroline Wozniacki, looked to be cruising with a 3-1 lead in the second set.