Cristiano Ronaldo can expect to start a handful of games this season from the substitutes bench despite making a big money move from Real Madrid to Juventus this summer, according to head coach Massimiliano Allegri.
Piotr Zielinski scored twice as Napoli came from two goals behind to beat AC Milan 3-2 and give new coach Carlo Ancelotti an unforgettable home debut, against the side where he spent eight seasons of his coaching career.
Sami Khedira hit a post for Juve when the game was goalless.
Ronaldo nearly got his goal midway through the second half, only for a deflected ball to bounce back off his heel just yards from the line to tee up Mandzukic to tuck home into an empty net.
Although Ronaldo would be expected to start week in week out for Juventus, something which seems more likely after Gonzalo Higuaín joined Milan, manager Allegri claims the Portugal global will be forced to feature in a number of cameo appearances throughout the season.
"Italian football is completely different to Spain".
Ronaldo's accidental assist sparked plenty of debate between football fans.
Ronaldo came close after 63 minutes but headed just wide after connecting with a Joao Cancelo cross and again threatened on 71 minutes but Strakosha tipped over. He is someone who goes forward very quickly, who is very mobile, we need to understand each other better. "We have to find a better balance".
Pjanic put Juve ahead with half an hour gone in Turin and Mandzukic made victory certain 15 minutes from time.
When Lazio last traveled to Allianz Stadium in October 2017, it defeated Juventus in a stunning 2-1 result, issuing Juve its first home loss in over two years.